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首页> 外文OA文献 >Anti-inflammatory and Immune-regulatory Effects of Subcutaneous Perillae Fructus Extract Injections on OVA-induced Asthma in Mice
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Anti-inflammatory and Immune-regulatory Effects of Subcutaneous Perillae Fructus Extract Injections on OVA-induced Asthma in Mice

机译：皮下紫苏提取物注射液对OVA诱导的小鼠哮喘的抗炎和免疫调节作用

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Perillae fructus (perilla seed) is a traditional medicinal herb used to treat bronchial asthma in Oriental medical clinics. ST36 is one of the most widely used acupuncture points, particularly for immune system regulation. Injection of an herbal extract into an acupuncture point (herbal acupuncture) is a therapeutic technique combining both acupuncture and herbal treatment. Perillae fructus extract was injected subcutaneously (Perillae fructus herbal acupuncture; PF-HA) at acupoint ST36 of OVA-induced asthmatic mice. The lung weight, bronchoalveolar fluid (BALF) cell count, the number of CCR3+, CD11b+, CD4+ and CD3e+/CD69+ cells in the lung, and the level of IgE, IL-4, IL-5 and IL-13 in BALF and serum were then measured. RT-PCR was used to measure the mRNA expression of IL-4, IL-5, IL-13 and TNF-α in the lung. Lung sections were analyzed histologically. PF-HA significantly reduced lung weight, the number of inflammatory cells in the lung and BALF, the levels of IgE and Th2 cytokines in BALF and serum, mRNA expression of Th2 cytokines in the lung, and pathological changes in lung tissue. Our results suggest that PF-HA may have an anti-inflammatory and immune-regulatory effect on bronchial allergic asthma by restoring the Th1/Th2 imbalance in the immune system and suppressing eosinophilic inflammation in airways.
机译：紫苏（紫苏种子）是东方医学诊所中用于治疗支气管哮喘的传统草药。 ST36是最广泛使用的穴位之一，特别是在免疫系统调节方面。将草药提取物注射到穴位（草药针灸）是一种结合针灸和草药治疗的治疗技术。在OVA诱发的哮喘小鼠的ST36穴位皮下注射紫苏提取物（紫苏中草药； PF-HA）。肺重量，支气管肺泡液（BALF）细胞计数，肺中CCR3 +，CD11b +，CD4 +和CD3e + / CD69 +细胞的数量以及BALF和血清中IgE，IL-4，IL-5和IL-13的水平然后进行测量。用RT-PCR检测肺中IL-4，IL-5，IL-13和TNF-α的mRNA表达。对肺切片进行组织学分析。 PF-HA显着降低了肺重量，肺和BALF中的炎症细胞数量，BALF和血清中的IgE和Th2细胞因子水平，肺中Th2细胞因子的mRNA表达以及肺组织病理变化。我们的结果表明，PF-HA可以通过恢复免疫系统中的Th1 / Th2失衡并抑制气道嗜酸性粒细胞炎症而对支气管过敏性哮喘产生抗炎和免疫调节作用。

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